Pyridine-2-carbonitrile → 6-Bromo-2-(2-pyridyl)-4H-1,3-benzothiazine-4-one

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Reaction Steps

5-Bromo-2-mercaptobenzoic acid (4.10 g, 17.6 mmol), 2-cyanopyridine (1.70 g, 16.3 mmol) and pyridine (50.0 ml) were refluxed for 9 hrs as described in Example 9. After cooling, the precipitated crystals were collected and recrystallized from hexane-chlorobenzene to give the titled compound (2.40 g, 45%).

Provenance & Evidence