Pyridine-2-carbonitrile → 7-Fluoro-2-(2-pyridyl)-4H-1,3-benzothiazine-4-one

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-fluoro-2-mercaptobenzoic acid (5.00 g, 29.0 mmol), 2-cyanopyridine (3.05 g, 29.3 mmol) and pyridine (30.0 ml) was refluxed at 135° C. for 48 hrs as described in Example 9. The reaction mixture was concentrated. The residue was subjected to a silica gel column chromatography and eluted with hexane-ethyl acetate (2:1, v/v). The resultant product was recrystallized from ethanol to give the titled compound (0.09 g, 1%).

Provenance & Evidence