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Cyanogen Bromide → Methyl 2-amino-1H-benzimidazole-6-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyanogen Bromide | HCID 10476 | — |
| 反応物 | 3,5-Diamino-2-methylbenzoic acid | HCID 135524 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Methyl 2-amino-1H-benzimidazole-6-carboxylate | HCID 17834337 | — |
反応手順
300 mg (1.8 mmol) of methyl 3,4-diaminobenzoate was stirred in 5 ml of water. 0.5 ml of a solution of 5 M of cyanogen bromide in acetonitrile was added to the obtained mixture, and they were stirred at room temperature for 20 minutes. The mixture was filtered. Aqueous ammonia was added to the filtrate. After the treatment with ethyl acetate as the extracting solvent by an ordinary method, the title compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710056B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-19be3b710f6043ff9d1a1cad7a13f50d |
| 出典メモ | uspto-grants-2004_03 |