HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 59750130, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | 2-[Benzyl(methyl)amino]pyridine-4-carbonitrile | HCID 24694833 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59750130 | HCID 59750130 | 30.5% |
Reaction Steps
Methyl thiosalicylate (0.70 g, 4.2 mmol) and 2-[N-benzyl-N-methylamino]isonicotinonitrile (0.46 g, 2.1 mmol) were dissolved in toluene (2.0 ml), and triethylamine (0.68 ml, 4.9 mmol) was added thereto. The reaction mixture was refluxed for 8 hrs, subjected to silica gel (50 g) column chromatography, eluted with hexane-ethyl-acetate (2:1, v/v) and recrystallized from ethanol to give the titled compound (0.23 g, 15%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767665B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-4bda2a57b283453dab4983793dafe3fd |
| Source note | uspto-grants-2010_08 |