Water → 2-(Morpholin-4-yl)pyridine-4-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Morpholine	HCID 8083	—
Reactant	2-Chloro-4-cyanopyridine	HCID 568638	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	2-(Morpholin-4-yl)pyridine-4-carbonitrile	HCID 14640856	71.1%

Reaction Conditions

Temperature	100 °C

Reaction Steps

2-Chloro-4-cyanopyridine (0.40 g, 2.9 mmol) was dissolved in N-methylpyrrolidone (2.0 ml), and morpholine (0.7 ml, 8.0 mmol) was added thereto. The reaction mixture was stirred at 100° C. for 2.5 hrs and combined with water to give precipitates, which were collected by filtration and dried to give the titled compound (0.39 g, 70%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07767665B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-b0bc8802bfae4dfbac604d075b19414e
Source note	uspto-grants-2010_08