HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(4-Phenyl-2-pyridyl)-4H-1,3-benzothiazine-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | 4-Phenyl-2-pyridinecarbonitrile | HCID 87758 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(4-Phenyl-2-pyridyl)-4H-1,3-benzothiazine-4-one | HCID 59750104 | 53% |
Reaction Steps
A mixture of methyl thiosalicylate (1.00 g, 5.9 mmol), 2-cyano-4-phenylpyridine (1.10 g, 5.9 mmol), triethylamine (1.30 ml, 9.0 mmol) and toluene (2.5 ml) was refluxed for 20 hrs. After cooling, the precipitated crystals were collected by filtration and recrystallized from ethanol to give the titled compound (0.99 g, 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767665B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-91eb6428f2b94a009d6e64f5151a335e |
| Source note | uspto-grants-2010_08 |