Triethylamine → 2-(6-Benzylthio-2-pyridyl)-4H-1,3-benzothiazine-4-one

HRID 499410노트

반응식

HRID 499410 반응식
[CH2:1]([S:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]#[N:16])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17](OC)(=[O:25])[C:18]1[C:19](=[CH:21][CH:22]=[CH:23][CH:24]=1)[SH:20].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:1]([S:8][C:9]1[N:10]=[C:11]([C:15]2[S:20][C:19]3[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=3[C:17](=[O:25])[N:16]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 21009Benzoic acid, 2-mercapto-, methyl esterHCID 229396226-(Benzylthio)picolinonitrile

생성물 1

HCID 229395932-(6-Benzylthio-2-pyridyl)-4H-1,3-benzothiazine-4-one수율 44%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2-Benzylthio-6-cyanopyridine (1.63 g, 7.22 mmol) and methyl thiosalicylate (1.21 g, 7.22 mmol) were dissolved in toluene (30 ml), and triethylamine (1.52 ml, 10.8 mmol) was added thereto. The reaction mixture was refluxed for 48 hrs. The solvent was evaporated and the residue was recrystallized from ethanol to give the titled compound (1.03 g, 44%) as white crystals.

후처리

  1. temperatureThe reaction mixture was refluxed for 48 hrs
  2. customThe solvent was evaporated
  3. customthe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-f723e47701474d83a954655e6f7486df
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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