反应详情

2-Mercapto-4-methoxybenzoic acid (1.26 g, 6.8 mmol) and tert-butyl 3-(6-cyano-2-pyridyl)propanoate (1.21 g, 5.2 mmol) were dissolved in pyridine (10 ml), and the reaction mixture was refluxed for 24 hrs. The reaction mixture was concentrated under reduced pressure, subjected to a silica gel column chromatography, eluted with hexane-ethyl acetate (1:1, v/v) and recrystallized from ethyl acetate-hexane to give the titled compound (0.96 g, 46%).

1. temperaturethe reaction mixture was refluxed for 24 hrs
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. washeluted with hexane-ethyl acetate (1:1
4. customv/v) and recrystallized from ethyl acetate-hexane