反应详情

2-Mercapto-4-methylbenzoic acid (1.56 g, 9.3 mmol) and tert-butyl 3-(6-cyano-2-pyridyl)propanoate (1.46 g, 6.3 mmol) were dissolved in pyridine (15 ml), and the mixture was refluxed for 6 hrs. The reaction mixture was concentrated under reduced pressure, subjected to silica gel column chromatography, eluted with hexane-ethyl acetate (3:2, v/v) and recrystallized from ethyl acetate-hexane to give the titled compound (1.29 g, 53%).

1. temperaturethe mixture was refluxed for 6 hrs
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. washeluted with hexane-ethyl acetate (3:2
4. customv/v) and recrystallized from ethyl acetate-hexane