反应详情

2-Mercapto-4-trifluoromethylbenzoic acid (1.59 g, 7.2 mmol) and tert-butyl 3-(6-cyano-2-pyridyl)propanoate (1.32 g, 5.7 mmol) were dissolved in pyridine (15 ml), and the mixture was refluxed for 15 hrs. The reaction mixture was concentrated under reduced pressure, subjected to a silica gel column chromatography, eluted with hexane-ethyl acetate (3:1, v/v) and recrystallized from ethyl acetate-hexane to give the titled compound (0.85 g, 34%).

1. temperaturethe mixture was refluxed for 15 hrs
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. washeluted with hexane-ethyl acetate (3:1
4. customv/v) and recrystallized from ethyl acetate-hexane