HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 4-(t-Butoxycarbonylamino)-2-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 4-(((Tert-butoxy)carbonyl)amino)-2-hydroxybenzoic acid | HCID 10332476 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 4-(t-Butoxycarbonylamino)-2-hydroxybenzoate | HCID 17834349 | — |
Reaction Steps
A mixture of 1.2 g of 4-(t-butoxycarbonylamino)-2-hydroxybenzoic acid, 900 mg of 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (WSC·HCl), 550 mg of 4-dimethylaminopyridine, 1 ml of ethanol and 30 ml of dichloromethane was stirred at room temperature. The reaction mixture was treated with dichloromethane as the extracting solvent in an ordinary manner and then purified by the silica gel chromatography (ethyl acetate/hexane) to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710056B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-6ad0c6b22fd34371956974c9cbee2ff2 |
| Source note | uspto-grants-2004_03 |