反应详情

tert-Butyl 3-(6-cyano-4-methyl-2-pyridyl)propanoate (0.69 g, 2.8 mmol) and 4-chlorothiosalicylic acid (1.05 g, 5.7 mmol) were dissolved in pyridine (10 ml). The mixture was refluxed for 22 hrs. The solvent was evaporated, and the residue was subjected to a silica gel column chromatography. The fractions eluted with hexane-ethyl acetate (3:1, v/v) were collected, concentrated and recrystallized from hexane-ethyl acetate to give the titled compound (0.33 g, 28%) as white crystals.

1. temperatureThe mixture was refluxed for 22 hrs
2. customThe solvent was evaporated
3. washThe fractions eluted with hexane-ethyl acetate (3:1
4. customv/v) were collected
5. concentrationconcentrated
6. customrecrystallized from hexane-ethyl acetate