化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 2-Fluoro-5-trifluoromethylbenzenethiol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 3-Ethoxythiocarbonylthio-4-fluorobenzotrifluoride | HCID 12097353 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Fluoro-5-trifluoromethylbenzenethiol | HCID 12097354 | — |
反応手順
The above-obtained 3-ethoxythiocarbonylthio-4-fluorobenzotrifluoride was dissolved in 100 ml of tetrahydrofuran without further purification. The solution was added dropwise to a suspension of 4.4 g of lithium aluminum hydride in 100 ml of tetrahydrofuran. The reaction mixture was stirred for 3 hours, followed by addition of diluted hydrochloric acid to adjust the pH to 1, and the mixture was extracted with ethyl acetate, giving 13 g of 4-fluoro-3-mercaptobenzotrifluoride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710062B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-35bc6c280a664c1ba9f36a0b7542836b |
| 出典メモ | uspto-grants-2004_03 |