HCID 59750108, compound → HCID 22939444, compound

HRID 499616Notes

Reaction equation

HRID 499616 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6](/[CH:8]=[CH:9]/[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:5]=[CH:4][N:3]=1>CO.[C].[Pd]>[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 1

HCID 59750108HCID 59750108, compound

Product 1

HCID 22939444HCID 22939444, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

tert-Butyl (E)-3-(2-methyl-4-pyridyl)-2-propenoate (4.4 g, 20 mmol) was dissolved in methanol (100 ml), and 10% palladium-carbon (0.45 g) was added thereto. The mixture was stirred under hydrogen atmosphere for 3 hrs. Palladium-carbon was filtered off, and the filtrate was concentrated to give the titled compound (4.4 g, 99%).

Workup

  1. filtrationPalladium-carbon was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-1b9f8e6b08e74a10adefc26be60d3bfd
Source dataset
uspto-grants-2010_08
Patent number
US07767665B2

Reaction notes

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