反应详情

Activated neutral aluminum oxide 90 (activity I, made by Merck Co.) (5 g) was added to a diethyl ether solution (10 mL) of 1-benzylpiperidin-4-spiro-2′-oxirane (0.50 g) and 4-butoxy-N-methylaniline (0.53 g) and stirred at room temperature overnight. Methanol (20 mL) was added to the reaction solution and stirred at room temperature for 2 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The residue obtained was purified by silica gel column chromatography (elution solvent; ethyl acetate) to obtain the titled compound (0.71 g).

1. stirringstirred at room temperature for 2 hours
2. filtrationThe reaction solution was filtered
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue obtained
5. customwas purified by silica gel column chromatography (elution solvent; ethyl acetate)