Acetonitrile → 4-[Hydroxy(diphenyl)methyl]-1-(2-phenylethyl)-1-azoniabicyclo[2.2.1]heptane bromide

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol (30.5 mg, 0.109 mmol) in 2 CH3CN/3 CHCl3 (2.5 mL) was added (2-bromoethyl)benzene (0.03 mL, 0.22 mmol). The solution was stirred at 60° C. for 16 h. The reaction was cooled down to room temperature. Trituration with ethyl acetate caused a solid to crash out of solution. This solid was filtered off, and washed with ethyl acetate to give the title compound (36.4 mg, 72%). EI-MS m/z 384 (M+) Rt (1.87 min).

Provenance & Evidence