1-(Bromomethyl)-4-(trifluoromethoxy)benzene → HCID 86622414, compound

HRID 499665Notes

Reaction equation

HRID 499665 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[OH:9])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[F:22][C:23]([O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][Br:34])=[CH:29][CH:28]=1)([F:25])[F:24]>CC#N>[Br-:34].[OH:9][C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]12[CH2:7][N+:1]([CH2:33][C:30]3[CH:31]=[CH:32][C:27]([O:26][C:23]([F:22])([F:24])[F:25])=[CH:28][CH:29]=3)([CH2:6][CH2:5]1)[CH2:2][CH2:3]2

Participants

4

Reactant 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 426258561-Azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol

Product 1

HCID 86622414HCID 86622414, compoundYield 72.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 2, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol (29.9 mg, 0.107 mmol) and 4-(bromomethyl)phenyl trifluoromethyl ether (51 mg, 0.20 mmol) in 2 CH3CN/3 CHCl3 (2.5 mL) were reacted to give the desired product (41.3 mg, 72%). EI-MS m/z 454 (M+) Rt (1.95 rain).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-16fca1b7fb2f447a8112083660f78a7d
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

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