Cyclohexane, (bromomethyl)- → HCID 16041586, compound

HRID 499669Notes

Reaction equation

HRID 499669 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[OH:9])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>CC#N>[Br-:22].[CH:24]1([CH2:23][N+:1]23[CH2:7][C:4]([C:8]([OH:9])([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)([CH2:5][CH2:6]2)[CH2:3][CH2:2]3)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 137636Cyclohexane, (bromomethyl)-HCID 426258561-Azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol

Product 1

HCID 16041586HCID 16041586, compoundYield 13%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 1, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol (33.0 mg, 0.118 mmol) and (bromomethyl)cyclohexane (0.03 mL, 0.21 mmol) in 2 CH3CN/3 CHCl3 (2.5 mL) were reacted to give the desired product (7 mg, 13%). EI-MS m/z 376 (M+) Rt (1.90 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b0fee73864b64e47b92f5943d5a5aea2
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

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