Acetonitrile → HCID 16041592, compound

HRID 499674Notes

Reaction equation

HRID 499674 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[OH:9])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:22]C[C:24]1[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=1.[CH3:34]C#N>>[Br-:22].[OH:9][C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]12[CH2:7][N+:1]([CH2:34][CH2:31][O:30][C:28]([C:27]3[CH:32]=[CH:33][CH:24]=[CH:25][CH:26]=3)=[O:29])([CH2:6][CH2:5]1)[CH2:2][CH2:3]2

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 256687Methyl 4-(bromomethyl)benzoateHCID 426258561-Azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol

Product 1

HCID 16041592HCID 16041592, compoundYield 7%

Procedure

Following the general procedure outlined in Example 1, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol (32.2 mg, 0.115 mmol) and methyl 4-(bromomethyl)benzoate (0.03 mL, 0.19 mmol) in 2 CH3CN/3 CHCl3 (2.5 mL) were reacted to give the desired product (4 mg, 7%). EI-MS m/z 428 (M+) Rt (1.69 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6eda179e62274b82bf49dcb5519992cc
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

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