3-Methoxybenzyl bromide → HCID 16041758, compound

HRID 499679Notes

Reaction equation

HRID 499679 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[OH:9])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][Br:31])[CH:25]=1>CC#N>[Br-:31].[OH:9][C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]12[CH2:7][N+:1]([CH2:30][C:26]3[CH:27]=[CH:28][CH:29]=[C:24]([O:23][CH3:22])[CH:25]=3)([CH2:6][CH2:5]1)[CH2:2][CH2:3]2

Participants

4

Reactant 2

HCID 40672073-Methoxybenzyl bromideHCID 426258561-Azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol

Product 1

HCID 16041758HCID 16041758, compoundYield 10%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 1, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol (29.3 mg, 0.105 mmol) and 3-(bromomethyl)phenyl methyl ether (0.03 mL, 0.21 mmol) in 2 CH3CN/3 CHCl3 (2.5 mL) were reacted to give the desired product (5 mg, 10%). EI-MS m/z 400 (M+) Rt (1.72 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0ed449aba8b44cfbb0acba66322ef679
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

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