Benzyl Bromide → HCID 16041936, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)acetonitrile (0.044 g, 0.152 mmol) in 2CH3CN/3CHCl3 (3.5 mL) was added (bromomethyl)benzene (0.030 mL, 0.252 mmol). The solution was heated to 60° C. for 16 h. The reaction was cooled to room temperature and concentrated under vacuum. The residue was taken up in DMSO and purified by Gilson preparatory HPLC (without TFA) to give the title compound (0.0417 g, 59.6%). EI-MS m/z 451 (M+) Rt (1.20 min).

Provenance & Evidence