Benzene, ((2-bromoethoxy)methyl)- → HCID 16041938, compound

HRID 499685Notes

Reaction equation

HRID 499685 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:9]#[N:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[C:23]1([CH2:29][O:30][CH2:31][CH2:32][Br:33])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[Br-:33].[C:9]([C:8]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:7][N+:1]([CH2:32][CH2:31][O:30][CH2:29][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)([CH2:6][CH2:5]1)[CH2:2][CH2:3]2)#[N:10]

Participants

3

Reactant 2

HCID 73833Benzene, ((2-bromoethoxy)methyl)-HCID 42625857HCID 42625857, compound

Product 1

HCID 16041938HCID 16041938, compoundYield 37%

Procedure

Following the general procedure outlined in Example 24, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)acetonitrile (0.044 g, 0.152 mmol) and 2-bromoethyl phenylmethyl ether (0.040 mL, 0.253 mmol) in 2CH3CN/3CHCl3 (3.5 mL) were reacted to give the desired product (0.0281 g, 37.0%). EI-MS m/z 423 (M+) Rt (2.02 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-1bfd91519f854232b933f74db03cdb48
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

Loading…