1-Bromo-3-methoxypropane → HCID 16041942, compound

HRID 499687Notes

Reaction equation

HRID 499687 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:9]#[N:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[CH3:23][O:24][CH2:25][CH2:26][CH2:27][Br:28]>>[Br-:28].[C:9]([C:8]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:7][N+:1]([CH2:27][CH2:26][CH2:25][O:24][CH3:23])([CH2:6][CH2:5]1)[CH2:2][CH2:3]2)#[N:10]

Participants

3

Reactant 2

HCID 5245511-Bromo-3-methoxypropaneHCID 42625857HCID 42625857, compound

Product 1

HCID 16041942HCID 16041942, compoundYield 41.3%

Procedure

Following the general procedure outlined in Example 24, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)acetonitrile (0.044 g, 0.152 mmol) and 3-bromopropyl methyl ether (0.035 g, 0.229 mmol) in 2CH3CN/3CHCl3 (3.5 mL) were reacted to give the desired product (0.0277 g, 41.3%). EI-MS m/z 361 (M+) Rt (1.58 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-a868bf6aee954dbbb75c9f4e50fa23f1
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

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