(3-Bromopropyl)benzene → HCID 16041944, compound

HRID 499688Notes

Reaction equation

HRID 499688 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:9]#[N:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:23][CH2:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[Br-:23].[C:9]([C:8]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:7][N+:1]([CH2:24][CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)([CH2:6][CH2:5]1)[CH2:2][CH2:3]2)#[N:10]

Participants

3

Reactant 2

HCID 12503(3-Bromopropyl)benzeneHCID 42625857HCID 42625857, compound

Product 1

HCID 16041944HCID 16041944, compoundYield 44.3%

Procedure

Following the general procedure outlined in Example 24, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)acetonitrile (0.044 g, 0.152 mmol) and (3-bromopropyl)benzene (0.035 mL, 0.230 mmol) in 2CH3CN/3CHCl3 (3.5 mL) were reacted to give the desired product (0.0328 g, 44.3%). EI-MS m/z 407 (M+) Rt (1.82 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-54421e28755143ca895a9fa7addfb32d
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

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