HCID 131728266, compound → HCID 69176521, compound

Participants

Reaction Steps

A mixture of 0.37 g of [1-(7-azido-5(S)-tert-butoxycarbonylamino-6(S)-hydroxy-3,3-dimethyl-heptanoyl)-1,2,3,4-tetrahydro-quinolin-3(R,S)-yl]-carbamic acid methyl ester and 75 mg of 10% Pd/C in 15 ml of methanol is hydrogenated at room temperature for 2 hours. The solid is removed by filtration over Hyflo® and the solution is concentrated. The title compound is obtained as a yellow oil from the residue by means of flash chromatography (SiO2 60 F). Rf=0.12 (200:40:1 dichloromethane-methanol-25% conc. ammonia); Rt=3.43 (gradient I).

Provenance & Evidence