Triethylamine → HCID 131728267, compound

Participants

Reaction Steps

0.007 ml Propan-2-sulfonyl chlorid are added to a solution of 0.026 g [1-(7-amino-5(S)-tert-butoxycarbonylamino-6(S)-hydroxy-3,3-dimethyl-heptanoyl)-1,2,3,4-tetrahydro-quinolin-3(R,S)-yl]-carbamic acid methyl ester (Example 18b) and 0.007 ml triethylamine in 1 ml dichlormethane at 0° C. After 5 hours, the reaction mixture is concentrated. The intermediate N-Boc derivative is identified from the residue by means of flash chromatography (SiO2 60 F) based on its Rf value. This is dissolved in 0.82 ml 4N HCl (in dioxane), stirred for 4 hours and concentrated. The residue is dissolved in 0.5 ml tert-butanol, frozen in liquid nitrogen and lyophilized to give the title compound which is identified from the residue based on its Rf value.

Provenance & Evidence