反应详情

800 mg (3.8 mmol) of 4-(4-amino-2-fluorophenyl)-3-morpholinone and 700 mg (3.22 mmol) of 5-chloro-N-(2-oxiranylmethyl)-2-thiophenecarboxamide are heated in 15 ml of ethanol and 1 ml of water under reflux for 6 hours. The mixture is evaporated in vacuo, the crystals which have separated out after treatment with ethyl acetate are filtered off with suction, and chromatography of the mother liquor results in 276 mg (17% of theory) of the target compound.

1. customThe mixture is evaporated in vacuo
2. customthe crystals which have separated out after treatment with ethyl acetate
3. filtrationare filtered off with suction, and chromatography of the mother liquor
4. customresults in 276 mg (17% of theory) of the target compound