Methyl iodide → HCID 178469908, compound

HRID 499835Notes

Reaction equation

HRID 499835 reaction equation
[SH:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.[CH3:12]I>CC(C)=O>[CH3:12][S:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178469909HCID 178469909, compound

Product 1

HCID 178469908HCID 178469908, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a suspension of ethyl 2-mercapto-1H-imidazole-4-carboxylate (4.00 g, 23.3 mmol) in acetone (30 mL) at room temperature, MeI (6 mL, 96.3 mmol) was added. During first 10 min of stirring, the suspension became clear, then it turned cloudy as product began to precipitate out. After being stirred at room temperature overnight, the precipitate was collected, dried on vacuum to give ethyl 2-(methylthio)-1H-imidazole-4-carboxylate (3.47 g).

Workup

  1. customto precipitate out
  2. stirringAfter being stirred at room temperature overnight
  3. customthe precipitate was collected
  4. customdried on vacuum

Sources & evidence

ORD record
ord-1c15081f7d954c7c9a4295166c3ac763
Source dataset
uspto-grants-2010_08
Patent number
US07767697B2

Reaction notes

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