Dimethylamine → HCID 59421897, compound

Participants

Reaction Steps

114.5 mg (0.2 mmol) of 2-[({4-({[(4-chloro-2-methylphenyl)amino]carbonyl}amino)-1-[4-(trifluoromethyl)benzyl]-1H-imidazol-2-yl}carbonyl)amino]ethyl chloroacetate (Example 26A) are dissolved in 2 ml of a 2 molar solution of dimethylamine in THF. The reaction mixture is shaken in a tightly closed reaction vessel at RT for 16 h and then left to stand at RT for 64 h. The reaction solution is then evaporated, and the residue from the evaporation is dissolved in DMF, filtered and purified by preparative HPLC (Method 9).

Provenance & Evidence