Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Ethanamine, 2,2,2-trifluoro- | HCID 9773 | — |
| Reactant | HCID 59421850 | HCID 59421850 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 86617204 | HCID 86617204 | — |
Reaction Steps
90 mg (0.19 mmol) of 1-butyl-N-(3-chloropropyl)-4-[({[4-(trifluoromethoxy)phenyl]-amino}carbonyl)amino]-1H-imidazole-2-carboxamide (Example 151) in 3 ml of 1,2-dimethoxyethane are mixed with 97 mg (0.97 mmol) of 2,2,2-trifluoroethylamine and 29 mg (0.19 mmol) of sodium iodide under argon and stirred at 90° C. overnight. The reaction mixture is concentrated in vacuo and purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07767704B2 |
|---|
| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-cb190b97a5804db4a10a59094352e4b5 |
|---|
| Source note | uspto-grants-2010_08 |
|---|
