HRID500012

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

反应SMILES：COCCCOc1cc([C@H]2[C@H](C(C)C)C[C@@H]([C@@H](O)C[C@H](COCc3ccccc3)C(C)C)N2C(=O)OC(C)(C)C)ccc1OC

HCID67304985

未命名化合物

PRODUCTS

产物

反应SMILES：COCCCOc1cc([C@H]2[C@H](C(C)C)C[C@@H]([C@@H](CO)C[C@H](CO)C(C)C)N2C(=O)OC(C)(C)C)ccc1OC

HCID11998866

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

A solution of 0.48 g of 8 in 1.5 mL of methanol is treated with 0.1 g of 10% palladium on charcoal. The suspension is stirred under an atmosphere of hydrogen until the uptake is stable. The suspension is filtered and the solid washed with 5 mL of methanol in two portions. Removal of the solvent in vacuum provides alcohol 9 as an oil. A negative [a]d (e.g. −34.1, −34.6) is found at c=1, CHCl3.

WORKUP

后处理

filtrationThe suspension is filtered
washthe solid washed with 5 mL of methanol in two portions
customRemoval of the solvent in vacuum

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-650f257124b44fc8a21498f67ec4b4bc
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07767831B2
来源说明: uspto-grants-2010_08

反应SMILES

[C:1]([O:5][C:6]([N:8]1[C@H:12]([C@@H:13](O)[CH2:14][C@H:15]([CH2:19][O:20]CC2C=CC=CC=2)[CH:16]([CH3:18])[CH3:17])[CH2:11][C@@H:10]([CH:29]([CH3:31])[CH3:30])[C@@H:9]1[C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:46][OH:47]>[Pd]>[C:1]([O:5][C:6]([N:8]1[C@H:12]([C@@H:13]([CH2:46][OH:47])[CH2:14][C@H:15]([CH2:19][OH:20])[CH:16]([CH3:17])[CH3:18])[CH2:11][C@@H:10]([CH:29]([CH3:31])[CH3:30])[C@@H:9]1[C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=1)=[O:7])([CH3:3])([CH3:4])[CH3:2]