1-Butanol → Butoxytrimethylsilane
Reaction equation
Cl[Si:2]([CH3:5])([CH3:4])[CH3:3].[CH2:6]([OH:10])[CH2:7][CH2:8][CH3:9].CN1C=CN=C1>>[CH3:3][Si:2]([CH3:5])([CH3:4])[O:10][CH2:6][CH2:7][CH2:8][CH3:9]Participants
4
Conditions
- Temperature
- 0 °C
Procedure
4.40 g (40.5 mmol) of chlorotrimethylsilane were added dropwise to a solution of 3.00 g (40.5 mmol) of 1-butanol and 11.1 g (135 mmol) of 1-methylimidazole while stirring at 0° C. The reaction mixture was stirred for another 15 minutes at 0-5° C. and for 15 minutes at 20° C., resulting in the formation of a liquid two-phase mixture. The upper phase was separated off to give 5.30 g (theory: 5.93 g) of 1-trimethylsilyloxybutane as a colorless oil having a purity of 90% (GC).
Workup
- stirringThe reaction mixture was stirred for another 15 minutes at 0-5° C. and for 15 minutes at 20° C.
- customresulting in the formation of a liquid two-phase mixture
- customThe upper phase was separated off
Sources & evidence
- ORD record
- ord-3bc64c8ed8d64a86a2dcc0f20a204dde
- Source dataset
- uspto-grants-2010_08
- Patent number
- US07767852B2
Reaction notes
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