反应详情

温度

0 °C

4.40 g (40.5 mmol) of chlorotrimethylsilane were added dropwise to a solution of 3.00 g (40.5 mmol) of 1-butanol and 11.1 g (135 mmol) of 1-methylimidazole while stirring at 0° C. The reaction mixture was stirred for another 15 minutes at 0-5° C. and for 15 minutes at 20° C., resulting in the formation of a liquid two-phase mixture. The upper phase was separated off to give 5.30 g (theory: 5.93 g) of 1-trimethylsilyloxybutane as a colorless oil having a purity of 90% (GC).

1. stirringThe reaction mixture was stirred for another 15 minutes at 0-5° C. and for 15 minutes at 20° C.
2. customresulting in the formation of a liquid two-phase mixture
3. customThe upper phase was separated off