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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 50006Generated: October 28, 2026

Water → 1-Chloro-3-(diethylamino)-2-propanol

https://huagongshe.com/reaction/50006

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantEpichlorohydrinHCID 7835—
ReactantDiethylamineHCID 8021—
Product1-Chloro-3-(diethylamino)-2-propanolHCID 5298859—

Reaction Conditions

Temperature31.5 °C

Reaction Steps

To 2-chloromethyloxirane (95 g, 1.03 mole) was added a mixture of water (3.08 g, 0.17 mole) and diethylamine (106.2 mL, 1.03 mole) at 30° C. The reaction mixture was then stirred at 28-35° C. for 6 hour and cooled to 20-25° C. to give 1-chloro-3-diethylamino-propan-2-ol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06710067B2
Source datasetuspto-grants-2004_03
ORD IDord-d962f808ded44640913508ebd5ccfc21
Source noteuspto-grants-2004_03