HCID 178445689, compound → HCID 178443911, compound

HRID 500086Notes

Reaction equation

HRID 500086 reaction equation
[CH2:1]([C:3]([CH2:24][CH3:25])=[CH:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12](=[O:23])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([O:21][CH3:22])[CH:15]=2)[CH2:7][CH2:6]1)[CH3:2]>C(O)C.[Pd]>[CH2:24]([CH:3]([CH2:1][CH3:2])[CH2:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12](=[O:23])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([O:21][CH3:22])[CH:15]=2)[CH2:7][CH2:6]1)[CH3:25]

Participants

4

Reactant 1

HCID 178445689HCID 178445689, compound

Product 1

HCID 178443911HCID 178443911, compoundYield 65.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The compound (0.07 g) of Example 90 was dissolved in ethanol (10 ml), 10% palladium/carbon (10 mg) was added to the solution, and the mixture was hydrogenated at room temperature. After 3 hours, the catalyst was removed by filtration from the reaction mixture, and the solvent was evaporated under reduced pressure from the filtrate. The residue was crystallized from diisopropyl ether to give 46 mg of the desired compound as a crystal.

Workup

  1. customwas hydrogenated at room temperature
  2. customthe catalyst was removed by filtration from the reaction mixture
  3. customthe solvent was evaporated under reduced pressure from the filtrate
  4. customThe residue was crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-0e61f3c97cd44f70b07fcbebc9f26ae9
Source dataset
uspto-grants-2010_08
Patent number
US07767854B2

Reaction notes

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