HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 500111Generated: October 30, 2026
6-(4-Fluorophenyl)-1,2,4-triazin-3-amine → 2-(4-Fluorophenyl)-7-[1-(4-methoxyphenyl)cyclopropyl]imidazo[1,2-b]-[1,2,4]-triazine
https://huagongshe.com/reaction/500111
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 6-(4-Fluorophenyl)-1,2,4-triazin-3-amine | HCID 67224067 | — |
| Reactant | Chloro[1-(4-methoxyphenyl)cyclopropyl]acetaldehyde | HCID 86621500 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(4-Fluorophenyl)-7-[1-(4-methoxyphenyl)cyclopropyl]imidazo[1,2-b]-[1,2,4]-triazine | HCID 25145510 | — |
Reaction Steps
A mixture of 6-(4-fluorophenyl)-1,2,4-triazin-3-amine (20.1 mg, 0.106 mmol) and chloro[1-(4-methoxyphenyl)cyclopropyl]acetaldehyde (53 mg, 0.24 mmol) in isopropyl alcohol (0.6 mL) was heated to 90° C. overnight. After cooling, the mixture was diluted with methanol and was purified by mass-guided RP-HPLC to afford the desired product. LCMS: (M+H)=361.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07767675B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-757814f36067445eb5f81669db0c49bb |
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| Source note | uspto-grants-2010_08 |
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