HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(4-Fluorophenyl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Chloro-5-(4-fluorophenyl)pyrimidine | HCID 20333351 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(4-Fluorophenyl)pyrimidin-2-amine | HCID 12946647 | — |
Reaction Steps
2-Chloro-5-(4-fluorophenyl)pyrimidine (376 mg) in 7M of ammonia in methanol (10 mL) in a sealed tube was heated at 50° C. overnight. After concentration, the product was obtained (360 g) which was used in the next reaction step without further purification. LCMS: (M+H)=190.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767675B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-fcebbcab1722486da4b0340766b1e6f9 |
| Source note | uspto-grants-2010_08 |