反应详情

温度

50 °C

60 mL of 50% aqueous sodium hydroxide was added to a mixture of 1-bromo-2-chloroethane (22.0 mL, 265 mmol), quinolin-6-ylacetonitrile (16.0 g, 66.6 mmol), and benzyltriethylammonium chloride (990 mg, 4.3 mmol) at 50° C. The reaction mixture was stirred at 50° C. for 3 h. After cooling to RT, the reaction mixture was poured into 100 mL water, and extracted with dichloromethane (3×100 mL). The combined organic extracts were dried over sodium sulfate, filtered through a pad of silica gel eluting with 20% ethyl acetate in dichloromethane. The filtrate was concentrated to give the desired product which was used in the next step without further purification. (12.4 g, 96%).

1. temperatureAfter cooling to RT
2. extractionextracted with dichloromethane (3×100 mL)
3. dry with materialThe combined organic extracts were dried over sodium sulfate
4. filtrationfiltered through a pad of silica gel eluting with 20% ethyl acetate in dichloromethane
5. concentrationThe filtrate was concentrated