HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 500156Generated: October 30, 2026
5-(1H-pyrazol-1-yl)pyrimidin-2-amine → 6-{1-[6-(1H-pyrazol-1-yl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline
https://huagongshe.com/reaction/500156
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-(1H-pyrazol-1-yl)pyrimidin-2-amine | HCID 67224965 | — |
| Reactant | Chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde | HCID 86621504 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6-{1-[6-(1H-pyrazol-1-yl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline | HCID 25143692 | — |
Reaction Steps
A mixture of 5-(1H-pyrazol-1-yl)pyrimidin-2-amine (0.08 g, 0.5 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (0.1 g, 0.5 mmol) in isopropanol (15 mL) was heated at 90° C. overnight. After cooling, the mixture was purified by RP-HPLC (pH 10) to afford the desired product. LCMS: (M+H)=353.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07767675B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-be590d165e584e9e823532dc293b41b1 |
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| Source note | uspto-grants-2010_08 |
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