HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 500201Generated: October 29, 2026
5-(4-Bromo-3-fluorophenyl)pyrimidin-2-amine → 6-{1-[6-(4-Bromo-3-fluorophenyl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline
https://huagongshe.com/reaction/500201
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-(4-Bromo-3-fluorophenyl)pyrimidin-2-amine | HCID 67223847 | — |
| Reactant | Chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde | HCID 86621504 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-{1-[6-(4-Bromo-3-fluorophenyl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline | HCID 67225168 | — |
Reaction Steps
A mixture of 5-(4-bromo-3-fluorophenyl)pyrimidin-2-amine (0.50 g, 1.9 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (0.463 g, 1.88 mol) in ethanol (20 mL) was stirred at 100° C. overnight. The solution was concentrated and the residue was purified by chromatography on silica gel with MeOH in CH2Cl2 (0-6%) to afford the desired compound. LCMS: (M+H)=458.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07767675B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-a1e486b41c8942309347e7c74c5e0c9b |
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| Source note | uspto-grants-2010_08 |
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