D-Proline → HCID 86621516, compound

Participants

Reaction Steps

N-Chlorosuccinimide (0.27 g, 0.0020 mol) was added to a mixture of tert-butyl[3-(3-oxopropyl)phenyl]carbamate (0.50 g, 0.0020 mol) and D-proline (0.05 g, 0.0004 mol) in methylene chloride (5 mL) at 0° C. The reaction mixture was stirred at RT for 2 h and concentrated. The residue was purified by chromatography on silica gel with 30% EtOAc in hexanes to afford the desired product (0.50 g, 88%). LCMS: (M+H)=209.9/211.9.

Provenance & Evidence