HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 500270Generated: October 29, 2026
1-[2-Chloro-1-hydroxy-2-(1-quinolin-6-ylcyclopropyl)ethyl]pyrrolidine-2,5-dione → HCID 59420967, compound
https://huagongshe.com/reaction/500270
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-[2-Chloro-1-hydroxy-2-(1-quinolin-6-ylcyclopropyl)ethyl]pyrrolidine-2,5-dione | HCID 67223833 | — |
| Reactant | 4-(2-aminopyrimidin-5-yl)-2-fluoro-N-methylbenzenesulfonamide | HCID 67225169 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 59420967 | HCID 59420967 | — |
Reaction Steps
A mixture of 4-(2-aminopyrimidin-5-yl)-2-fluoro-N-methylbenzenesulfonamide (20 mg, 0.07 mmol) and 1-[2-chloro-1-hydroxy-2-(1-quinolin-6-ylcyclopropyl)ethyl]pyrrolidine-2,5-dione (24 mg, 0.07 mmol) in ethanol (0.4 mL) was stirred overnight at 105° C. The reaction mixture was purified by RP-HPLC (pH 10) to afford the desired product. LCMS: (M+H)=474.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07767675B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-be151a66a2d248cc852b99abd1d7bda4 |
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| Source note | uspto-grants-2010_08 |
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