HCID 67223283, compound → HCID 67224078, compound

HRID 500278Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:21]=[CH:20][C:11]([C:12]([NH:14][CH:15]([CH3:19])[C:16]([OH:18])=[O:17])=[O:13])=[C:10]([F:22])[CH:9]=2)=[CH:4][N:3]=1.Cl[CH:24]([C:27]1([C:30]2[CH:31]=[C:32]3[C:37](=[CH:38][CH:39]=2)[N:36]=[CH:35][CH:34]=[CH:33]3)[CH2:29][CH2:28]1)[CH:25]=O>C(O)C>[F:22][C:10]1[CH:9]=[C:8]([C:5]2[CH:6]=[N:7][C:2]3[N:3]([C:24]([C:27]4([C:30]5[CH:31]=[C:32]6[C:37](=[CH:38][CH:39]=5)[N:36]=[CH:35][CH:34]=[CH:33]6)[CH2:29][CH2:28]4)=[CH:25][N:1]=3)[CH:4]=2)[CH:21]=[CH:20][C:11]=1[C:12]([NH:14][CH:15]([CH3:19])[C:16]([OH:18])=[O:17])=[O:13]

Participants

Conditions

Temperature: 90 °C

Procedure

A mixture of 2-[4-(2-aminopyrimidin-5-yl)-2-fluorobenzoyl]aminopropanoic acid (0.20 g, 0.66 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (0.19 g, 0.79 mmol) in ethanol (4.0 mL) was stirred overnight at 90° C. The mixture was concentrated to afford the crude product. LCMS: (M+H)=496.1.

Workup

concentrationThe mixture was concentrated

Sources & evidence

ORD record: ord-b408f050fe4f4b35aec0d897fba7bc9e
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07767675B2

Reaction notes

Loading…