HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 4-Bromo-2-(bromomethyl)-1-chlorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | (5-Bromo-2-chlorophenyl)methanol | HCID 5074766 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Bromo-2-(bromomethyl)-1-chlorobenzene | HCID 11558280 | — |
Reaction Conditions
| Temperature | 5 °C |
|---|
Reaction Steps
4.0 g N-bromosuccinimide are slowly added to a solution of 5.0 g of 4-bromo-1-chloro-2-hydroxymethyl-benzene and 5.9 g triphenylphosphine in 50 mL of tetrahydrofuran chilled to 5° C. After 1 h stirring at ambient temperature the precipitate is filtered off, and the solvent is eliminated in vacuo. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 50:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772191B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-d40362f948634dbfaa7021ad47c5ebf7 |
| Source note | uspto-grants-2010_08 |