3,5-Dimethylisoxazole-4-isocyanate → 1-(3,5-Dimethylisoxazol-4-yl)carbamoylcyclopropanesulfonamide tert-butylcarbamate

HRID 500364Notes

Reaction equation

HRID 500364 reaction equation
[C:1]([NH:5][C:6](=[O:8])[OH:7])([CH3:4])([CH3:3])[CH3:2].C[O:10][CH2:11][C:12]1([S:15]([NH2:18])(=[O:17])=[O:16])[CH2:14][CH2:13]1.[CH3:19][C:20]1[O:24][N:23]=[C:22]([CH3:25])[C:21]=1[N:26]=C=O>>[C:1]([NH:5][C:6](=[O:7])[OH:8])([CH3:4])([CH3:3])[CH3:2].[CH3:25][C:22]1[C:21]([NH:26][C:11]([C:12]2([S:15]([NH2:18])(=[O:17])=[O:16])[CH2:14][CH2:13]2)=[O:10])=[C:20]([CH3:19])[O:24][N:23]=1

Participants

3

Reactant 2

HCID 27362663,5-Dimethylisoxazole-4-isocyanateHCID 667523821-Methoxymethylcyclopropylsulfonylamine tert-butylcarbamate

Product 1

HCID 667524801-(3,5-Dimethylisoxazol-4-yl)carbamoylcyclopropanesulfonamide tert-butylcarbamateYield 100%

Procedure

This compound was obtained in a crude 100% yield according to the procedure described for the synthesis of 1-methoxymethylcyclopropylsulfonylamine tert-butylcarbamate except that 1.20 equivalents of 3,5-dimethylisoxazole-4-isocyanate was used as the electrophile. The compound was taken directly into the next reaction without purification.

Workup

  1. customThis compound was obtained in a crude 100% yield
  2. customThe compound was taken directly into the next reaction without purification

Sources & evidence

ORD record
ord-cc2497703b9d4b769fbb44874fa34e0d
Source dataset
uspto-grants-2010_08
Patent number
US07772183B2

Reaction notes

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