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HRID500384

反应详情

EQUATION

反应方程式

HRID 500384 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)c1ccc(-c2ccccc2)cc1
HCID84151

[1,1'-Biphenyl]-4-carbonyl chloride

C13H9ClO

结构：CC(C)(C)OC(=O)NC1CCCOCC=CC2CC2(C(=O)NS(=O)(=O)C2CC2)NC(=O)C2CC(O)CN2C1=O
HCID72260122

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1CCCOCC=CC2CC2(C(=O)NS(=O)(=O)C2CC2)NC(=O)C2CC(OC(=O)c3ccc(-c4ccccc4)cc3)CN2C1=O
HCID73227125

未命名化合物

收率 27%

PROCEDURE

实验过程

Prepared by way of method I using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-10-oxatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and 4-biphenylcarbonyl chloride (113 mg, 0.53 mmol). The final trituration (diethyl ether/hexane) and filtration gave 35 mg (27%) of 18-(4-biphenylcarbonyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-10-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 98.9% pure (HPLC), MS m/z 749 (M−H)−, HRMS: calcd. 751.3013 and found 751.3008 (M+H)+, mp 160-162° C.

WORKUP

后处理

  1. customPrepared by way of method I
  2. filtrationThe final trituration (diethyl ether/hexane) and filtration