HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → HCID 72445389, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | tert-butyl N-[4-(cyclopropylsulfonylcarbamoyl)-18-hydroxy-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-14-yl]carbamate | HCID 68797769 | — |
| Product | HCID 72445389 | HCID 72445389 | 15.3% |
Reaction Steps
Prepared by way of method I using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and benzoyl chloride (41 μL, 0.35 mmol). The final trituration (diethyl ether/hexane) and filtration gave 18 mg (15%) of 18-benzoyloxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diazatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 97.0% pure (HPLC), MS m/z 673 (M+H)+, HRMS: calcd. 673.2907 and found 673.2908 (M+H)+, mp 140-142° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772183B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-3f8e621f0e1b43458a563dd044b5c3d9 |
| Source note | uspto-grants-2010_08 |