HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(Chlorocarbonyl)phenyl]acetic acid → HCID 77506315, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(Chlorocarbonyl)phenyl]acetic acid | HCID 20464134 | — |
| Reactant | tert-butyl N-[4-(cyclopropylsulfonylcarbamoyl)-18-hydroxy-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-14-yl]carbamate | HCID 68797769 | — |
| Product | HCID 77506315 | HCID 77506315 | 7% |
Reaction Steps
Prepared by way of method I using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and 4-caboxymethylbenzoyl chloride (70 mg, 0.35 mmol). The final trituration (diethyl ether/hexane) and filtration gave 9.0 mg (7.0%) of 18-(4-carboxymethylbenzoyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diazatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 99.9% pure (HPLC), MS m/z 729 (M−H)−, HRMS: calcd. 731.2962 and found 731.2957 (M+H)+, mp 154-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772183B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-8800524dbbbb4011becf51acc8acb0f1 |
| Source note | uspto-grants-2010_08 |