HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1H-pyrazol-1-yl)benzoyl chloride → HCID 72445408, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1H-pyrazol-1-yl)benzoyl chloride | HCID 2776474 | — |
| Reactant | tert-butyl N-[4-(cyclopropylsulfonylcarbamoyl)-18-hydroxy-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-14-yl]carbamate | HCID 68797769 | — |
| Product | HCID 72445408 | HCID 72445408 | 7.7% |
Reaction Steps
Prepared by way of method I using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and 4-(1-pyrazolyl)benzoyl chloride (183 mg, 0.88 mmol). The final trituration (diethyl ether/hexane) and filtration gave 10 mg (7.7%) of 18-(4-[1-pyrazolyl]benzoyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diazatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 99.9% pure (HPLC), MS m/z 737 (M−H)−, HRMS: calcd. 739.3125 and found 739.3109 (M+H)+, mp 167-169° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772183B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-03820dcd82bc4a67b7ba526985782524 |
| Source note | uspto-grants-2010_08 |