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HRID500407

反应详情

EQUATION

反应方程式

HRID 500407 的结构方程式

REACTANTS

反应物

2
结构：O=C=Nc1ccccc1Oc1ccccc1
HCID2733389

1-Isocyanato-2-phenoxybenzene

C13H9NO2

结构：CC(C)(C)OC(=O)NC1COCCCC=CC2CC2(C(=O)NS(=O)(=O)C2CC2)NC(=O)C2CC(O)CN2C1=O
HCID72260127

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1COCCCC=CC2CC2(C(=O)NS(=O)(=O)C2CC2)NC(=O)C2CC(OC(=O)Nc3ccccc3Oc3ccccc3)CN2C1=O
HCID86612085

未命名化合物

收率 15.3%

PROCEDURE

实验过程

Prepared by way of method III using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and 2-phenoxyphenyl isocyanate (94 mg, 0.53 mmol). The final trituration (diethyl ether/hexane) and filtration gave 21 mg (15%) of 18-(2-phenoxyphenylaminocarbonyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 99.2% pure (HPLC), MS m/z 780 (M−H)−, HRMS: calcd. 799.3337 and found 799.3325 (M+NH4)−, mp 151-153° C.

WORKUP

后处理

  1. customPrepared by way of method III
  2. filtrationThe final trituration (diethyl ether/hexane) and filtration