HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Amino-2-methoxyphenyl)methanol → 3-Hydroxymethyl-4-propyloxyaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Amino-2-methoxyphenyl)methanol | HCID 237567 | — |
| Reactant | (5-Nitro-2-propoxyphenyl)methanol | HCID 21904358 | — |
| Product | 3-Hydroxymethyl-4-propyloxyaniline | HCID 21904368 | 37% |
Reaction Steps
This compound was prepared by reduction of 5-nitro-2-propyloxy-benzylalcohol using the method described for the preparation of 3-hydroxymethyl-4-methoxyaniline in 37% yield: 1H NMR (DMSO-d6, 500 MHz) δ 6.66 (d, 1H, J=2.5 Hz), 6.60 (d, 1H, J=8.6 Hz), 6.35 (dd, 1H, J=2.7 and 8.5 Hz), 4.79 (t, 1H, J=5.8 Hz), 4.54 (br, 2H), 4.37 (d, 2H, J=6.1 Hz), 3.74 (t, 2H, J=6.4 Hz), 1.65 (m, 2H), 0.94 (t, 3H, J=7.4 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772216B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-c1defbcc5f7b4734b95d67f6cf376059 |
| Source note | uspto-grants-2010_08 |